Nuclear Cloning, Epigenetic Reprogramming, and Cellular Differentiation
نویسندگان
چکیده
منابع مشابه
Nuclear cloning, epigenetic reprogramming, and cellular differentiation.
The full-term development of sheep, cows, goats, pigs and mice has been achieved through the transfer of somatic cell nuclei into enucleated oocytes. Despite these successes, mammalian cloning remains an inefficient process, with a preponderance of reconstructed embryos failing at early- to mid-gestation stages of development. The small percentage of conceptuses that survive to term are charact...
متن کاملEpigenetic Control of Reprogramming and Cellular Differentiation
1Dulbecco Telethon Institute (DTI), IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00143 Rome, Italy 2National Research Council, Institute of Translational Pharmacology, via Fosso del Cavaliere 100, 00133 Rome, Italy 3 Institute of Predictive and Personalized Medicine of Cancer (IMPPC), 08916 Badalona, Spain 4 Sanford-Burnham Institute for Medical Research, La Jolla, CA 920...
متن کاملNuclear cloning and epigenetic reprogramming of the genome.
Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at most a few percent of manipulated embryos resulting in live births. Many of those that survive to term succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Cloned embryos derived from donors, such as embryonic stem cells, that may require little or no re...
متن کاملEpigenetic reprogramming and nuclear transfer
Nuclear transfer, also referred to as cloning, attracted public attention when the first mammal, the sheep Dolly, was cloned from an adult cell. In this review, we highlight some of the milestones reached in the 50 years following the first nuclear transplantations in frogs. We also address the problems associated with nuclear transfer and provide an survey on current stem-cell technology. In t...
متن کاملCloning in Cattle: Nuclear architecture and epigenetic status of chromatin during reprogramming of donor cell nuclei
Chromosomes occupy non-random tissue-specific positions in the interphase nucleus thatcorrelate with the chromosome size and gene richness; they can also have probabilisticallypreferred neighbors. Earlier studies reached opposite conclusions about the degree of thetransmission through mitosis of chromosome arrangement present in a given cell. None ofthese studies, however, a...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2004
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2004.69.19